WASHINGTON — Sixteen states have now reported 153 instances of great, vaping-related respiratory sicknesses prior to now two months, and most of the sufferers are youngsters or younger adults.

In an announcement on Wednesday, the Facilities for Illness Management and Prevention mentioned that the entire instances occurred in individuals who acknowledged vaping both nicotine or tetrahydrocannabinol, referred to as THC, the high-inducing chemical in marijuana.

Federal and state officers say that they’re mystified as to what’s inflicting the sicknesses, however that it doesn’t seem that an infectious illness is accountable. Nobody product or system is widespread among the many instances, the company mentioned. It additionally was unclear whether or not a contaminant in a used cartridge or a home-brewed concoction of vaping liquids contributed to among the illnesses.

The sufferers, most of whom have been adolescents or younger adults, have been admitted to hospitals with issue respiration. Many additionally reported chest ache, vomiting and fatigue.

Essentially the most significantly ailing sufferers had severe lung harm that required therapy with oxygen and days on a ventilator. Some are anticipated to have everlasting lung harm. Some extreme instances have been earlier reported in Wisconsin, Minnesota, Illinois and California.

In an electronic mail, the C.D.C. mentioned that whereas extra examine was wanted, vaping both hashish or nicotine may very well be harmful.

“E-cigarettes are nonetheless pretty new, and scientists are nonetheless studying about their long-term well being results,” mentioned Brian King, deputy director for analysis translation within the company’s smoking and well being workplace. “Hostile respiratory results related to e-cigarette use may very well be the results of a wide range of elements, together with meant and unintended constituents of those merchandise.”

Mr. King mentioned quite a few components in e-cigarette aerosol might hurt the lungs, together with ultrafine particles that may very well be inhaled deeply, heavy metals like lead, risky natural compounds and cancer-causing brokers.

The C.D.C. urged medical doctors to report suspected instances to their state well being companies. The Meals and Drug Administration can also be gathering details about sicknesses associated to e-cigarettes and vaping.

“Oftentimes persons are vaping each nicotine and the THC merchandise, so it’s unclear which can be accountable,” mentioned Dr. Michael Lynch, medical director of the poison heart on the College of Pittsburgh Medical Heart. “In all probability this has been taking place often and we haven’t been conscious of it, as a result of the affiliation with vaping wasn’t essentially made. Now persons are looking out, which is sweet, as a result of we wish to make certain we now have an understanding of how prevalent a problem that is.”

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